• Biomechanical properties of native and cultured red blood cells–Interplay of shape, structure and biomechanics 

      Bernecker, Claudia; Lima, Maria; Kolesnik, Tatjana; Lampl, Annika; Ciubotaru, Catalin; Leita, Riccardo; Kolb, Dagmar; Fröhlich, Eleonore; Schlenke, Peter; Holzapfel, Gerhard; Dorn, Isabel; Cojoc, Dan (Peer reviewed; Journal article, 2022)
      Modern medicine increases the demand for safe blood products. Ex vivo cultured red blood cells (cRBC) are eagerly awaited as a standardized, safe source of RBC. Established culture models still lack the terminal cytoskeletal ...
    • Cholesterol Deficiency Causes Impaired Osmotic Stability of Cultured Red Blood Cells 

      Bernecker, Claudia; Köfeler, Harald; Pabst, Georg; Trötzmüller, Martin; Kolb, Dagmar; Strohmayer, Karl; Trajanoski, Slave; Holzapfel, Gerhard; Schlenke, Peter; Dorn, Isabel (Journal article; Peer reviewed, 2019)
      Ex vivo generation of red blood cells (cRBCs) is an attractive tool in basic research and for replacing blood components donated by volunteers. As a prerequisite for the survival of cRBCs during storage as well as in the ...
    • Deficiency of B vitamins leads to cholesterol-independent atherogenic transformation of the aorta 

      Almer, Gunter; Opriessnig, Peter; Wolinski, Heimo; Sommer, Gerhard; Diwoky, Clemens; Lechleitner, Margarete; Kolb, Dagmar; Bubalo, Vladimir; Brunner, Markus S.; Schwarz, Andreas N.; Leitinger, Gerd; Schoiswohl, Gabriele; Marsche, Gunther; Niedrist, Tobias; Schauer, Silvia; Oswald, Wolfgang; Groselj-Strele, Andrea; Paar, Margret; Cvirn, Gerhard; Hoefler, Gerald; Rechberger, Gerald N.; Herrmann, Markus; Frank, Saša; Holzapfel, Gerhard; Kratky, Dagmar; Mangge, Harald; Hörl, Gerd; Tehlivets, Oksana (Peer reviewed; Journal article, 2022)
      Atherosclerosis, the leading cause of cardiovascular disease responsible for the majority of deaths worldwide, cannot be sufficiently explained by established risk factors, including hypercholesterolemia. Elevated plasma ...
    • Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice 

      Amor, Melina; Bianco, Valentina; Buerger, Martin; Lechleitner, Margarete; Vujić, Nemanja; Dobrijević, Anja; Akhmetshina, Alena; Pirchheim, Anita; Schwarz, Birgit; Pessentheiner, Ariane R.; Baumgartner, Franziska; Rampitsch, Katharina; Schauer, Silvia; Klobučar, Iva; Degoricija, Vesna; Pregartner, Gudrun; Kummer, Daniel; Svecla, Monika; Sommer, Gerhard; Kolb, Dagmar; Holzapfel, Gerhard; Hoefler, Gerald; Frank, Saša; Norata, Giuseppe Danilo; Kratky, Dagmar (Journal article; Peer reviewed, 2023)
      Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic ...
    • Poro-viscoelastic material parameter identification of brain tissue-mimicking hydrogels 

      Kainz, Manuel P.; Greiner, Alexander; Hinrichsen, Jan; Kolb, Dagmar; Comellas, Ester; Steinmann, Paul; Budday, Silvia; Terzano, Michele; Holzapfel, Gerhard (Peer reviewed; Journal article, 2023)
      Understanding and characterizing the mechanical and structural properties of brain tissue is essential for developing and calibrating reliable material models. Based on the Theory of Porous Media, a novel nonlinear ...